The Transcription Factor GLI1 Mediates TGFβ1 Driven EMT in Hepatocellular Carcinoma via a SNAI1-Dependent Mechanism

The role of the epithelial-to-mesenchymal transition (EMT) during hepatocellular carcinoma (HCC) progression is well established, however the regulatory mechanisms modulating this phenomenon remain unclear. Here, we demonstrate that transcription factor glioma-associated oncogene 1 (GLI1) modulates...

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Main Authors: Zheng, Xin, Rumie Vittar, Natalia B., Gai, Xiaohong, Fernandez-Barrena, Maite G., Moser, Catherine D., Hu, Chunling, Almada, Luciana L., McCleary-Wheeler, Angela L., Elsawa, Sherine F., Vrabel, Anne M., Shire, Abdirashid M., Comba, Andrea, Thorgeirsson, Snorri S., Kim, Youngsoo, Liu, Qingguang, Fernandez-Zapico, Martin E., Roberts, Lewis R.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501480/
https://ncbi.nlm.nih.gov/pubmed/23185371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0049581
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