Hyperactivity of the Ero1α Oxidase Elicits Endoplasmic Reticulum Stress but No Broad Antioxidant Response

Oxidizing equivalents for the process of oxidative protein folding in the endoplasmic reticulum (ER) of mammalian cells are mainly provided by the Ero1α oxidase. The molecular mechanisms that regulate Ero1α activity in order to harness its oxidative power are quite well understood. However, the over...

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Hlavní autoři: Hansen, Henning Gram, Schmidt, Jonas Damgård, Søltoft, Cecilie Lützen, Ramming, Thomas, Geertz-Hansen, Henrik Marcus, Christensen, Brian, Sørensen, Esben Skipper, Juncker, Agnieszka Sierakowska, Appenzeller-Herzog, Christian, Ellgaard, Lars
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501080/
https://ncbi.nlm.nih.gov/pubmed/23027870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.405050
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