Disulphide production by Ero1α–PDI relay is rapid and effectively regulated

The molecular networks that control endoplasmic reticulum (ER) redox conditions in mammalian cells are incompletely understood. Here, we show that after reductive challenge the ER steady-state disulphide content is restored on a time scale of seconds. Both the oxidase Ero1α and the oxidoreductase pr...

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Hauptverfasser: Appenzeller-Herzog, Christian, Riemer, Jan, Zito, Ester, Chin, King-Tung, Ron, David, Spiess, Martin, Ellgaard, Lars
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2957208/
https://ncbi.nlm.nih.gov/pubmed/20802462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.203
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