Disulphide production by Ero1α–PDI relay is rapid and effectively regulated

The molecular networks that control endoplasmic reticulum (ER) redox conditions in mammalian cells are incompletely understood. Here, we show that after reductive challenge the ER steady-state disulphide content is restored on a time scale of seconds. Both the oxidase Ero1α and the oxidoreductase pr...

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Detalhes bibliográficos
Main Authors: Appenzeller-Herzog, Christian, Riemer, Jan, Zito, Ester, Chin, King-Tung, Ron, David, Spiess, Martin, Ellgaard, Lars
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2957208/
https://ncbi.nlm.nih.gov/pubmed/20802462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.203
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