Hyperactivity of the Ero1α Oxidase Elicits Endoplasmic Reticulum Stress but No Broad Antioxidant Response

Oxidizing equivalents for the process of oxidative protein folding in the endoplasmic reticulum (ER) of mammalian cells are mainly provided by the Ero1α oxidase. The molecular mechanisms that regulate Ero1α activity in order to harness its oxidative power are quite well understood. However, the over...

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Detalhes bibliográficos
Main Authors: Hansen, Henning Gram, Schmidt, Jonas Damgård, Søltoft, Cecilie Lützen, Ramming, Thomas, Geertz-Hansen, Henrik Marcus, Christensen, Brian, Sørensen, Esben Skipper, Juncker, Agnieszka Sierakowska, Appenzeller-Herzog, Christian, Ellgaard, Lars
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501080/
https://ncbi.nlm.nih.gov/pubmed/23027870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.405050
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