A novel disulphide switch mechanism in Ero1α balances ER oxidation in human cells

Oxidative maturation of secretory and membrane proteins in the endoplasmic reticulum (ER) is powered by Ero1 oxidases. To prevent cellular hyperoxidation, Ero1 activity can be regulated by intramolecular disulphide switches. Here, we determine the redox-driven shutdown mechanism of Ero1α, the housek...

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Autori principali: Appenzeller-Herzog, Christian, Riemer, Jan, Christensen, Brian, Sørensen, Esben S, Ellgaard, Lars
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2585162/
https://ncbi.nlm.nih.gov/pubmed/18833192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.202
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