A novel disulphide switch mechanism in Ero1α balances ER oxidation in human cells

Oxidative maturation of secretory and membrane proteins in the endoplasmic reticulum (ER) is powered by Ero1 oxidases. To prevent cellular hyperoxidation, Ero1 activity can be regulated by intramolecular disulphide switches. Here, we determine the redox-driven shutdown mechanism of Ero1α, the housek...

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Autors principals: Appenzeller-Herzog, Christian, Riemer, Jan, Christensen, Brian, Sørensen, Esben S, Ellgaard, Lars
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2008
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2585162/
https://ncbi.nlm.nih.gov/pubmed/18833192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.202
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