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A novel disulphide switch mechanism in Ero1α balances ER oxidation in human cells
Oxidative maturation of secretory and membrane proteins in the endoplasmic reticulum (ER) is powered by Ero1 oxidases. To prevent cellular hyperoxidation, Ero1 activity can be regulated by intramolecular disulphide switches. Here, we determine the redox-driven shutdown mechanism of Ero1α, the housek...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2585162/ https://ncbi.nlm.nih.gov/pubmed/18833192 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.202 |
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