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Proteasomal Degradation of Nod2 Protein Mediates Tolerance to Bacterial Cell Wall Components
The innate immune system serves as the first line of defense by detecting microbes and initiating inflammatory responses. Although both Toll-like receptor (TLR) and nucleotide binding domain and leucine-rich repeat (NLR) proteins are important for this process, their excessive activation is hazardou...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3501029/ https://ncbi.nlm.nih.gov/pubmed/23019338 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.410027 |
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