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Nod2 is required for the regulation of commensal microbiota in the intestine

Mutations in the Nod2 gene are among the strongest genetic risk factors in the pathogenesis of ileal Crohn's disease, but the exact contributions of Nod2 to intestinal mucosal homeostasis are not understood. Here we show that Nod2 plays an essential role in controlling commensal bacterial flora...

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Autors principals: Petnicki-Ocwieja, Tanja, Hrncir, Tomas, Liu, Yuen-Joyce, Biswas, Amlan, Hudcovic, Tomas, Tlaskalova-Hogenova, Helena, Kobayashi, Koichi S.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2747201/
https://ncbi.nlm.nih.gov/pubmed/19805227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0907722106
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