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Induction and rescue of Nod2-dependent Th1-driven granulomatous inflammation of the ileum

Mutations in the NOD2 gene are strong genetic risk factors for ileal Crohn’s disease. However, the mechanism by which these mutations predispose to intestinal inflammation remains a subject of controversy. We report that Nod2-deficient mice inoculated with Helicobacter hepaticus, an opportunistic pa...

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Hlavní autoři: Biswas, Amlan, Liu, Yuen-Joyce, Hao, Liming, Mizoguchi, Atsushi, Salzman, Nita H., Bevins, Charles L., Kobayashi, Koichi S.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2930434/
https://ncbi.nlm.nih.gov/pubmed/20679225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1003363107
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