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Proteasomal Degradation of Nod2 Protein Mediates Tolerance to Bacterial Cell Wall Components

The innate immune system serves as the first line of defense by detecting microbes and initiating inflammatory responses. Although both Toll-like receptor (TLR) and nucleotide binding domain and leucine-rich repeat (NLR) proteins are important for this process, their excessive activation is hazardou...

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Библиографические подробности
Главные авторы: Lee, Kyoung-Hee, Biswas, Amlan, Liu, Yuen-Joyce, Kobayashi, Koichi S.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2012
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501029/
https://ncbi.nlm.nih.gov/pubmed/23019338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.410027
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