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Ceramide-induced autophagy: To junk or to protect cells?

Ceramide is a sphingolipid bioactive molecule that induces apoptosis and other forms of cell death, and triggers macroautophagy (referred to below as autophagy). Like amino acid starvation, ceramide triggers autophagy by interfering with the mTOR-signaling pathway, and by dissociating the Beclin 1:B...

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Detalhes bibliográficos
Main Authors: Pattingre, Sophie, Bauvy, Chantal, Levade, Thierry, Levine, Beth, Codogno, Patrice
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501009/
https://ncbi.nlm.nih.gov/pubmed/19337026
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