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Ceramide-induced autophagy: To junk or to protect cells?

Ceramide is a sphingolipid bioactive molecule that induces apoptosis and other forms of cell death, and triggers macroautophagy (referred to below as autophagy). Like amino acid starvation, ceramide triggers autophagy by interfering with the mTOR-signaling pathway, and by dissociating the Beclin 1:B...

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Bibliografiske detaljer
Main Authors: Pattingre, Sophie, Bauvy, Chantal, Levade, Thierry, Levine, Beth, Codogno, Patrice
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501009/
https://ncbi.nlm.nih.gov/pubmed/19337026
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