Detection of 2-hydroxyglutaric acid in vivo by proton magnetic resonance spectroscopy in U87 glioma cells overexpressing isocitrate dehydrogenase–1 mutation

The arginine 132 (R132) mutation of isocitrate dehydrogenase –1 (IDH1(R132)) results in production of 2-hydroxyglutarate (2-HG) and is associated with a better prognosis compared with wild-type (WT) in glioma patients. The majority of lower-grade gliomas express IDH1(R132), whereas this mutation is...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Lazovic, Jelena, Soto, Horacio, Piccioni, David, Lo Ru, Jerry R., Li, Sichen, Mirsadraei, Leili, Yong, William, Prins, Robert, Liau, Linda M., Ellingson, Benjamin M., Cloughesy, Timothy F., Lai, Albert, Pope, Whitney B.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2012
Gaiak:
Clinical Investigations
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3499014/
https://ncbi.nlm.nih.gov/pubmed/23090985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nos258
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