Detection of 2-hydroxyglutaric acid in vivo by proton magnetic resonance spectroscopy in U87 glioma cells overexpressing isocitrate dehydrogenase–1 mutation

The arginine 132 (R132) mutation of isocitrate dehydrogenase –1 (IDH1(R132)) results in production of 2-hydroxyglutarate (2-HG) and is associated with a better prognosis compared with wild-type (WT) in glioma patients. The majority of lower-grade gliomas express IDH1(R132), whereas this mutation is...

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Hlavní autoři: Lazovic, Jelena, Soto, Horacio, Piccioni, David, Lo Ru, Jerry R., Li, Sichen, Mirsadraei, Leili, Yong, William, Prins, Robert, Liau, Linda M., Ellingson, Benjamin M., Cloughesy, Timothy F., Lai, Albert, Pope, Whitney B.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2012
Témata:
Clinical Investigations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3499014/
https://ncbi.nlm.nih.gov/pubmed/23090985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nos258
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