Detection of 2-hydroxyglutaric acid in vivo by proton magnetic resonance spectroscopy in U87 glioma cells overexpressing isocitrate dehydrogenase–1 mutation

The arginine 132 (R132) mutation of isocitrate dehydrogenase –1 (IDH1(R132)) results in production of 2-hydroxyglutarate (2-HG) and is associated with a better prognosis compared with wild-type (WT) in glioma patients. The majority of lower-grade gliomas express IDH1(R132), whereas this mutation is...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Lazovic, Jelena, Soto, Horacio, Piccioni, David, Lo Ru, Jerry R., Li, Sichen, Mirsadraei, Leili, Yong, William, Prins, Robert, Liau, Linda M., Ellingson, Benjamin M., Cloughesy, Timothy F., Lai, Albert, Pope, Whitney B.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Oxford University Press 2012
विषय:
Clinical Investigations
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3499014/
https://ncbi.nlm.nih.gov/pubmed/23090985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nos258
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