Detection of 2-hydroxyglutaric acid in vivo by proton magnetic resonance spectroscopy in U87 glioma cells overexpressing isocitrate dehydrogenase–1 mutation

The arginine 132 (R132) mutation of isocitrate dehydrogenase –1 (IDH1(R132)) results in production of 2-hydroxyglutarate (2-HG) and is associated with a better prognosis compared with wild-type (WT) in glioma patients. The majority of lower-grade gliomas express IDH1(R132), whereas this mutation is...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Lazovic, Jelena, Soto, Horacio, Piccioni, David, Lo Ru, Jerry R., Li, Sichen, Mirsadraei, Leili, Yong, William, Prins, Robert, Liau, Linda M., Ellingson, Benjamin M., Cloughesy, Timothy F., Lai, Albert, Pope, Whitney B.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2012
Sujets:
Clinical Investigations
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3499014/
https://ncbi.nlm.nih.gov/pubmed/23090985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nos258
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