Integration of 2-hydroxyglutarate-proton magnetic resonance spectroscopy into clinical practice for disease monitoring in isocitrate dehydrogenase-mutant glioma

BACKGROUND: The majority of WHO grades II and III gliomas harbor a missense mutation in the metabolic gene isocitrate dehydrogenase (IDH) and accumulate the metabolite R-2-hydroxyglutarate (R-2HG). Prior studies showed that this metabolite can be detected in vivo using proton magnetic-resonance spec...

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Udgivet i:Neuro Oncol
Main Authors: de la Fuente, Macarena I., Young, Robert J., Rubel, Jennifer, Rosenblum, Marc, Tisnado, Jamie, Briggs, Samuel, Arevalo-Perez, Julio, Cross, Justin R., Campos, Carl, Straley, Kimberly, Zhu, Dongwei, Dong, Chuanhui, Thomas, Alissa, Omuro, Antonio A., Nolan, Craig P., Pentsova, Elena, Kaley, Thomas J., Oh, Jung H., Noeske, Ralph, Maher, Elizabeth, Choi, Changho, Gutin, Philip H., Holodny, Andrei I., Yen, Katharine, DeAngelis, Lisa M., Mellinghoff, Ingo K., Thakur, Sunitha B.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2016
Fag:
Neuroimaging
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4724186/
https://ncbi.nlm.nih.gov/pubmed/26691210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nov307
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