Integration of 2-hydroxyglutarate-proton magnetic resonance spectroscopy into clinical practice for disease monitoring in isocitrate dehydrogenase-mutant glioma

BACKGROUND: The majority of WHO grades II and III gliomas harbor a missense mutation in the metabolic gene isocitrate dehydrogenase (IDH) and accumulate the metabolite R-2-hydroxyglutarate (R-2HG). Prior studies showed that this metabolite can be detected in vivo using proton magnetic-resonance spec...

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Bibliografiska uppgifter
I publikationen:Neuro Oncol
Huvudupphovsmän: de la Fuente, Macarena I., Young, Robert J., Rubel, Jennifer, Rosenblum, Marc, Tisnado, Jamie, Briggs, Samuel, Arevalo-Perez, Julio, Cross, Justin R., Campos, Carl, Straley, Kimberly, Zhu, Dongwei, Dong, Chuanhui, Thomas, Alissa, Omuro, Antonio A., Nolan, Craig P., Pentsova, Elena, Kaley, Thomas J., Oh, Jung H., Noeske, Ralph, Maher, Elizabeth, Choi, Changho, Gutin, Philip H., Holodny, Andrei I., Yen, Katharine, DeAngelis, Lisa M., Mellinghoff, Ingo K., Thakur, Sunitha B.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2016
Ämnen:
Neuroimaging
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4724186/
https://ncbi.nlm.nih.gov/pubmed/26691210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nov307
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