Integration of 2-hydroxyglutarate-proton magnetic resonance spectroscopy into clinical practice for disease monitoring in isocitrate dehydrogenase-mutant glioma

BACKGROUND: The majority of WHO grades II and III gliomas harbor a missense mutation in the metabolic gene isocitrate dehydrogenase (IDH) and accumulate the metabolite R-2-hydroxyglutarate (R-2HG). Prior studies showed that this metabolite can be detected in vivo using proton magnetic-resonance spec...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Neuro Oncol
Hauptverfasser: de la Fuente, Macarena I., Young, Robert J., Rubel, Jennifer, Rosenblum, Marc, Tisnado, Jamie, Briggs, Samuel, Arevalo-Perez, Julio, Cross, Justin R., Campos, Carl, Straley, Kimberly, Zhu, Dongwei, Dong, Chuanhui, Thomas, Alissa, Omuro, Antonio A., Nolan, Craig P., Pentsova, Elena, Kaley, Thomas J., Oh, Jung H., Noeske, Ralph, Maher, Elizabeth, Choi, Changho, Gutin, Philip H., Holodny, Andrei I., Yen, Katharine, DeAngelis, Lisa M., Mellinghoff, Ingo K., Thakur, Sunitha B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2016
Schlagworte:
Neuroimaging
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4724186/
https://ncbi.nlm.nih.gov/pubmed/26691210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nov307
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge