Efficient Monitoring of In Vivo Pig-a Gene Mutation and Chromosomal Damage: Summary of 7 Published Studies and Results From 11 New Reference Compounds

The ability to effectively monitor gene mutation and micronucleated reticulocyte (MN-RET) frequency in short-term and repeated dosing schedules was investigated using the recently developed flow cytometric Pig-a mutation assay and flow cytometric micronucleus analysis. Eight reference genotoxicants...

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Main Authors: Dertinger, Stephen D., Phonethepswath, Souk, Avlasevich, Svetlana L., Torous, Dorothea K., Mereness, Jared, Bryce, Steven M., Bemis, Jeffrey C., Bell, Sara, Weller, Pamela, MacGregor, James T.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3498746/
https://ncbi.nlm.nih.gov/pubmed/22923490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfs258
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