Islet-Specific CTL Cloned from a Type 1 Diabetes Patient Cause Beta-Cell Destruction after Engraftment into HLA-A2 Transgenic NOD/SCID/IL2RG Null Mice

Despite increasing evidence that autoreactive CD8 T-cells are involved in both the initiation of type 1 diabetes (T1D) and the destruction of beta-cells, direct evidence for their destructive role in-vivo is lacking. To address a destructive role for autoreactive CD8 T-cells in human disease, we ass...

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Detalhes bibliográficos
Main Authors: Unger, Wendy W. J., Pearson, Todd, Abreu, Joana R. F., Laban, Sandra, van der Slik, Arno R., der Kracht, Sacha Mulder-van, Kester, Michel G. D., Serreze, Dave V., Shultz, Leonard D., Griffioen, Marieke, Drijfhout, Jan Wouter, Greiner, Dale L., Roep, Bart O.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3498321/
https://ncbi.nlm.nih.gov/pubmed/23155466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0049213
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