ERK1/2 and p38 MAPKs Are Complementarily Involved in Estradiol 17ß-d-Glucuronide-Induced Cholestasis: Crosstalk with cPKC and PI3K

OBJECTIVE: The endogenous, cholestatic metabolite estradiol 17ß-d-glucuronide (E(2)17G) induces endocytic internalization of the canalicular transporters relevant to bile formation, Bsep and Mrp2. We evaluated here whether MAPKs are involved in this effect. DESIGN: ERK1/2, JNK1/2, and p38 MAPK activ...

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Bibliografiske detaljer
Main Authors: Boaglio, Andrea C., Zucchetti, Andrés E., Toledo, Flavia D., Barosso, Ismael R., Sánchez Pozzi, Enrique J., Crocenzi, Fernando A., Roma, Marcelo G.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3498151/
https://ncbi.nlm.nih.gov/pubmed/23166621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0049255
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