Sequential Activation of Classic PKC and Estrogen Receptor α Is Involved in Estradiol 17ß-D-Glucuronide-Induced Cholestasis

Estradiol 17ß-d-glucuronide (E17G) induces acute cholestasis in rat with endocytic internalization of the canalicular transporters bile salt export pump (Abcb11) and multidrug resistance-associated protein 2 (Abcc2). Classical protein kinase C (cPKC) and PI3K pathways play complementary roles in E17...

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Autores principales: Barosso, Ismael R., Zucchetti, Andrés E., Boaglio, Andrea C., Larocca, M. Cecilia, Taborda, Diego R., Luquita, Marcelo G., Roma, Marcelo G., Crocenzi, Fernando A., Sánchez Pozzi, Enrique J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3507741/
https://ncbi.nlm.nih.gov/pubmed/23209816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0050711
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