Adaptive downregulation of Cl(-)/HCO(3)(-) exchange activity in rat hepatocytes under experimental obstructive cholestasis

In obstructive cholestasis, there is an integral adaptive response aimed to diminish the bile flow and minimize the injury of bile ducts caused by increased intraluminal pressure and harmful levels of bile salts and bilirrubin. Canalicular bicarbonate secretion, driven by the anion exchanger 2 (AE2)...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS One
Prif Awduron: Miszczuk, Gisel S., Banales, Jesus M., Zucchetti, Andrés E., Pisani, Gerardo B., Boaglio, Andrea C., Saez, Elena, Medina, Juan F., Roma, Marcelo G., Crocenzi, Fernando A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2019
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6383990/
https://ncbi.nlm.nih.gov/pubmed/30789925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0212215
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