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Deletion of the Cl(−)/HCO(3)(−) exchanger pendrin downregulates calcium-absorbing proteins in the kidney and causes calcium wasting

BACKGROUND. The epithelial calcium channel (ECaC) (TRPV5) and the Cl(−)/HCO(3)(−) exchanger pendrin (SLC26A4) are expressed on the apical membrane of tubular cells in the distal nephron and play essential roles in calcium re-absorption and bicarbonate secretion, respectively, in the kidney. METHODS....

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Main Authors: Barone, Sharon, Amlal, Hassane, Xu, Jie, Soleimani, Manoocher
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3315671/
https://ncbi.nlm.nih.gov/pubmed/21873623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ndt/gfr505
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