Deletion of the anion exchanger Slc26a4 (pendrin) decreases apical Cl(−)/HCO(3)(−) exchanger activity and impairs bicarbonate secretion in kidney collecting duct

The anion exchanger Pendrin, which is encoded by SLC26A4 (human)/Slc26a4 (mouse) gene, is localized on the apical membrane of non-acid-secreting intercalated (IC) cells in the kidney cortical collecting duct (CCD). To examine its role in the mediation of bicarbonate secretion in vivo and the apical...

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Autors principals: Amlal, Hassane, Petrovic, Snezana, Xu, Jie, Wang, Zhaohui, Sun, Xuming, Barone, Sharon, Soleimani, Manoocher
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2010
Matèries:
Membrane Transporters, Ion Channels and Pumps
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2904254/
https://ncbi.nlm.nih.gov/pubmed/20375274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00033.2010
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