Probenecid Pre-treatment Downregulates the Kidney Cl(-)/HCO(3)(-) Exchanger (Pendrin) and Potentiates Hydrochlorothiazide-Induced Diuresis

Background: Probenecid is a uricosuric agent that in addition to exerting a positive ionotropic effect in the heart, blocks the ATP transporter Pannexin 1 and inhibits the Cl(-)/HCO(3)(-) exchanger, pendrin. In the kidney, pendrin blunts the loss of salt wasting secondary to the inhibition of the th...

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Detalhes bibliográficos
Publicado no:Front Physiol
Main Authors: Barone, Sharon, Xu, Jie, Zahedi, Kamyar, Brooks, Marybeth, Soleimani, Manoocher
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6050369/
https://ncbi.nlm.nih.gov/pubmed/30050451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2018.00849
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