Double knockout of pendrin and Na-Cl cotransporter (NCC) causes severe salt wasting, volume depletion, and renal failure

The Na-Cl cotransporter (NCC), which is the target of inhibition by thiazides, is located in close proximity to the chloride-absorbing transporter pendrin in the kidney distal nephron. Single deletion of pendrin or NCC does not cause salt wasting or excessive diuresis under basal conditions, raising...

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Main Authors: Soleimani, Manoocher, Barone, Sharon, Xu, Jie, Shull, Gary E., Siddiqui, Faraz, Zahedi, Kamyar, Amlal, Hassane
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2012
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421168/
https://ncbi.nlm.nih.gov/pubmed/22847418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1202671109
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