Ca(2+)-DEPENDENT PROTEIN KINASE C ISOFORMS ARE CRITICAL TO ESTRADIOL 17β-D-GLUCURONIDE-INDUCED CHOLESTASIS IN THE RAT

The endogenous estradiol metabolite estradiol 17β-D-glucuronide (E(2)17G) induces an acute cholestasis in rat liver coincident with retrieval of the canalicular transporters Bsep (Abcc11) and Mrp2 (Abcc2) and their associated loss of function. We assessed the participation of Ca(2+)-dependent PKC is...

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Bibliografiske detaljer
Main Authors: Crocenzi, Fernando A., Sánchez Pozzi, Enrique J., Ruiz, María Laura, Zucchetti, Andrés E., Roma, Marcelo G., Mottino, Aldo D., Vore, Mary
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3004396/
https://ncbi.nlm.nih.gov/pubmed/18972403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.22532
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