ERK1/2 and p38 MAPKs Are Complementarily Involved in Estradiol 17ß-d-Glucuronide-Induced Cholestasis: Crosstalk with cPKC and PI3K

OBJECTIVE: The endogenous, cholestatic metabolite estradiol 17ß-d-glucuronide (E(2)17G) induces endocytic internalization of the canalicular transporters relevant to bile formation, Bsep and Mrp2. We evaluated here whether MAPKs are involved in this effect. DESIGN: ERK1/2, JNK1/2, and p38 MAPK activ...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Boaglio, Andrea C., Zucchetti, Andrés E., Toledo, Flavia D., Barosso, Ismael R., Sánchez Pozzi, Enrique J., Crocenzi, Fernando A., Roma, Marcelo G.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3498151/
https://ncbi.nlm.nih.gov/pubmed/23166621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0049255
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki