Isolation of Chinese hamster cell mutants deficient in dihydrofolate reductase activity.
Mutants of Chinese hamster ovary cells lacking dihydrofolate reductase (tetrahydrofolate dehydrogenase, 7,8-dihydrofolate:NADP+ oxidoreductase; EC 1.5.1.3) activity were isolated after mutagenesis and exposure to high-specific-activity [3H]deoxyuridine as a selective agent. Fully deficient mutants c...
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| Опубликовано в:: | Proc Natl Acad Sci U S A |
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| Главные авторы: | , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
1980
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC349802/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6933469/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.77.7.4216 |
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