The Vpx Lentiviral Accessory Protein Targets SAMHD1 for Degradation in the Nucleus

Sterile alpha motif domain- and HD domain-containing protein 1 (SAMHD1) is a deoxynucleoside triphosphohydrolase that restricts the replication of lentiviruses in myeloid cells by hydrolyzing the cellular deoxynucleotide triphosphates to a level below that which is required for reverse transcription...

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Autori principali: Hofmann, Henning, Logue, Eric C., Bloch, Nicolin, Daddacha, Waaqo, Polsky, Sylvie B., Schultz, Megan L., Kim, Baek, Landau, Nathaniel R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2012
Soggetti:
Virus-Cell Interactions
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3497686/
https://ncbi.nlm.nih.gov/pubmed/22973040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01657-12
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