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Contribution of NS1 Effector Domain Dimerization to Influenza A Virus Replication and Virulence
Conserved tryptophan-187 facilitates homodimerization of the influenza A virus NS1 protein effector domain. We generated a mutant influenza virus strain expressing NS1-W187R to destabilize this self-interaction. NS1-W187R protein exhibited lower double-stranded RNA (dsRNA)-binding activity, showed a...
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| Main Authors: | , , , |
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| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
American Society for Microbiology
2012
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3497675/ https://ncbi.nlm.nih.gov/pubmed/22993153 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02237-12 |
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