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Contribution of NS1 Effector Domain Dimerization to Influenza A Virus Replication and Virulence

Conserved tryptophan-187 facilitates homodimerization of the influenza A virus NS1 protein effector domain. We generated a mutant influenza virus strain expressing NS1-W187R to destabilize this self-interaction. NS1-W187R protein exhibited lower double-stranded RNA (dsRNA)-binding activity, showed a...

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Bibliografiske detaljer
Main Authors: Ayllon, Juan, Russell, Rupert J., García-Sastre, Adolfo, Hale, Benjamin G.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3497675/
https://ncbi.nlm.nih.gov/pubmed/22993153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02237-12
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