Cellular Adaptation to Anthrax Lethal Toxin-Induced Mitochondrial Cholesterol Enrichment, Hyperpolarization, and Reactive Oxygen Species Generation through Downregulating MLN64 in Macrophages

Cellular adaptation to different stresses related to survival and function has been demonstrated in several cell types. Anthrax lethal toxin (LeTx) induces rapid cell death, termed “pyroptosis,” by activating NLRP1b/caspase-1 in murine macrophages. We and others (S. D. Ha et al., J. Biol. Chem. 282:...

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Hauptverfasser: Ha, Soon-Duck, Park, Sangwook, Han, Chae Young, Nguyen, Marilyn L., Kim, Sung Ouk
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2012
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3497600/
https://ncbi.nlm.nih.gov/pubmed/23028046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00494-12
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