Inhibition of Interleukin 1β (IL-1β) Expression by Anthrax Lethal Toxin (LeTx) Is Reversed by Histone Deacetylase 8 (HDAC8) Inhibition in Murine Macrophages

Many pathogenic microbes often release toxins that subvert the host's immune responses to render the environment suitable for their survival and proliferation. LeTx is one of the toxins causing immune paralysis by cleaving and inactivating the mitogen-activated protein kinase (MAPK) kinases (ME...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Ha, Soon-Duck, Reid, Chantelle, Meshkibaf, Shahab, Kim, Sung Ouk
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2016
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4861443/
https://ncbi.nlm.nih.gov/pubmed/26912657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.695809
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