Cathepsin B-mediated Autophagy Flux Facilitates the Anthrax Toxin Receptor 2-mediated Delivery of Anthrax Lethal Factor into the Cytoplasm

Anthrax lethal toxin (LeTx) is a virulence factor secreted by Bacillus anthracis and has direct cytotoxic effects on most cells once released into the cytoplasm. The cytoplasmic delivery of the proteolytically active component of LeTx, lethal factor (LF), is carried out by the transporter component,...

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Detalhes bibliográficos
Main Authors: Ha, Soon-Duck, Ham, Boram, Mogridge, Jeremy, Saftig, Paul, Lin, Shengcai, Kim, Sung Ouk
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Membrane Transport, Structure, Function, and Biogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804368/
https://ncbi.nlm.nih.gov/pubmed/19858192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.065813
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