Two Clinical Isolates of Candida glabrata Exhibiting Reduced Sensitivity to Amphotericin B Both Harbor Mutations in ERG2

Two novel isolates of Candida glabrata exhibiting reduced sensitivity to amphotericin B (MIC, 8 μg ml(−1)) were found to be ERG2 mutants, wherein Δ(8)-sterol intermediates comprised >90% of the total cellular sterol fraction. Both harbored an alteration at Thr(121) in ERG2; the corresponding resi...

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Main Authors: Hull, Claire M., Bader, Oliver, Parker, Josie E., Weig, Michael, Gross, Uwe, Warrilow, Andrew G. S., Kelly, Diane E., Kelly, Steven L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2012
Fag:
Mechanisms of Resistance
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3497184/
https://ncbi.nlm.nih.gov/pubmed/23027188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01145-12
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