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Investigational agent MLN9708/2238 targets tumor-suppressor miR33b in MM cells

miRs play a critical role in tumor pathogenesis as either oncogenes or tumor-suppressor genes. However, the role of miRs and their regulation in response to proteasome inhibitors in multiple myeloma (MM) is unclear. In the current study, miR profiling in proteasome inhibitor MLN2238-treated MM.1S MM...

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Bibliografische gegevens
Hoofdauteurs: Tian, Ze, Zhao, Jian-jun, Tai, Yu-Tzu, Amin, Samir B., Hu, Yiguo, Berger, Allison J., Richardson, Paul, Chauhan, Dharminder, Anderson, Kenneth C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2012
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3496955/
https://ncbi.nlm.nih.gov/pubmed/22983447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-01-401794
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