Induction of Endoplasmic Reticulum Stress Genes, BiP and Chop, in Genetic and Environmental Models of Retinal Degeneration

PURPOSE. Endoplasmic reticulum (ER) stress has been observed in animal models of retinitis pigmentosa expressing P23H rhodopsin. We compared levels of tightly induced ER stress genes, Binding of immunoglobulin protein (BiP) and CCAAT/enhancer-binding protein homologous protein (Chop), in seven addit...

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Hauptverfasser: Kroeger, Heike, Messah, Carissa, Ahern, Kelly, Gee, Jason, Joseph, Victory, Matthes, Michael T., Yasumura, Douglas, Gorbatyuk, Marina S., Chiang, Wei-Chieh, LaVail, Matthew M., Lin, Jonathan H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Association for Research in Vision and Ophthalmology 2012
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3495601/
https://ncbi.nlm.nih.gov/pubmed/23074209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.12-10221
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