Structure-Based Discovery of BM-957 as a Potent Small-Molecule Inhibitor of Bcl-2 and Bcl-xL Capable of Achieving Complete Tumor Regression

Bcl-2 and Bcl-xL anti-apoptotic proteins are attractive cancer therapeutic targets. We have previously reported the design of 4,5-diphenyl-1H-pyrrole-3-carboxylic acids as a class of potent Bcl-2/Bcl-xL inhibitors. In the present study, we report our structure-based optimization for this class of co...

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Bibliographische Detailangaben
Hauptverfasser: Chen, Jianfang, Zhou, Haibin, Aguilar, Angelo, Liu, Liu, Bai, Longchuan, McEachern, Donna, Yang, Chao-Yie, Meagher, Jennifer L., Stuckey, Jeanne A., Wang, Shaomeng
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3495162/
https://ncbi.nlm.nih.gov/pubmed/23030453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm3010306
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