Anion channel blockers inhibit lysosomal enzyme secretion from human neutrophils without affecting generation of superoxide anion.

The role of permeant anions in lysosomal enzyme secretion from human neutrophils was investigated by means of anion-channel-blocking agents: 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS), 4-acetamido-4'-isothiocyanostilbene-2,2'-disulfonic acid (SITS), and pyridoxal phosphate. Lysosomal en...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Korchak, H M, Eisenstat, B A, Hoffstein, S T, Dunham, P B, Weissmann, G
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1980
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC349475/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6248861/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.77.5.2721
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