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The Regulation of Multiple p53 Stress Responses is Mediated through MDM2
The MDM2 oncogene is a key negative regulator of the p53 tumor suppressor protein. MDM2 and p53 form an autoregulatory feedback loop to tightly control the proper cellular responses to various stress signals in order to prevent mutations and tumor formation. The levels and function of the MDM2 prote...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
SAGE Publications
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3494373/ https://ncbi.nlm.nih.gov/pubmed/23150753 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1947601912454734 |
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