Functional Interaction of the Ankylosing Spondylitis-associated Endoplasmic Reticulum Aminopeptidase 1 Polymorphism and HLA-B27 in Vivo

The association of ERAP1 with ankylosing spondylitis (AS) among HLA-B27-positive individuals suggests that ERAP1 polymorphism may affect pathogenesis by altering peptide-dependent features of the HLA-B27 molecule. Comparisons of HLA-B*27:04-bound peptidomes from cells expressing different natural va...

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Autori principali: García-Medel, Noel, Sanz-Bravo, Alejandro, Van Nguyen, Dung, Galocha, Begoña, Gómez-Molina, Patricia, Martín-Esteban, Adrián, Alvarez-Navarro, Carlos, de Castro, José A. López
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Biochemistry and Molecular Biology 2012
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3494199/
https://ncbi.nlm.nih.gov/pubmed/22918227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M112.019588
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