Peptide Handling by HLA-B27 Subtypes Influences Their Biological Behavior, Association with Ankylosing Spondylitis and Susceptibility to Endoplasmic Reticulum Aminopeptidase 1 (ERAP1)

HLA-B27 is strongly associated with ankylosing spondylitis (AS). We analyzed the relationship between structure, peptide specificity, folding, and stability of the seven major HLA-B27 subtypes to determine the role of their constitutive peptidomes in the pathogenicity of this molecule. Identificatio...

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Detalhes bibliográficos
Publicado no:Mol Cell Proteomics
Main Authors: García-Medel, Noel, Sanz-Bravo, Alejandro, Alvarez-Navarro, Carlos, Gómez-Molina, Patricia, Barnea, Eilon, Marcilla, Miguel, Admon, Arie, de Castro, José A. López
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4256490/
https://ncbi.nlm.nih.gov/pubmed/25187574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M114.039214
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