A Single Neonatal Exposure to Aflatoxin B(1) Induces Prolonged Genetic Damage in Two Loci of Mouse Liver

Aflatoxin B (1) (AFB(1)) is a risk factor for hepatocellular carcinoma in humans. Infant, but not adult, mice are sensitive to AFB(1)-induced liver carcinogenesis; a single dose during the neonatal period leads to hepatocellular carcinoma in adulthood. Earlier work defined the mutational spectrum in...

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Autors principals: Wattanawaraporn, Roongtiwa, Woo, Leslie L., Belanger, Crystal, Chang, Shiou-chi, Adams, Jillian E., Trudel, Laura J., Bouhenguel, Jason T., Egner, Patricia A., Groopman, John D., Croy, Robert G., Essigmann, John M., Wogan, Gerald N.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3493187/
https://ncbi.nlm.nih.gov/pubmed/22539618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfs151
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