Aflatoxin B(1)-DNA Adduct Formation and Mutagenicity in Livers of Neonatal Male and Female B6C3F1 Mice

Exposure to genotoxic chemicals at a young age increases cancer incidence later in life. Aflatoxin B(1) (AFB(1)) is a potent genotoxin that induces hepatocellular carcinoma (HCC) in many animal species and in humans. Whereas adult mice are insensitive to aflatoxin-induced carcinogenesis, mice treate...

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Главные авторы: Woo, Leslie L., Egner, Patricia A., Belanger, Crystal L., Wattanawaraporn, Roongtiwa, Trudel, Laura J., Croy, Robert G., Groopman, John D., Essigmann, John M., Wogan, Gerald N.
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2011
Предметы:
Carcinogenicity
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3143467/
https://ncbi.nlm.nih.gov/pubmed/21507988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfr087
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