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Dynamic interactions of high Cdt1 and geminin levels regulate S-phase in early Xenopus embryos
Cdt1 plays a key role in licensing DNA for replication. In the somatic cells of metazoans, both Cdt1 and its natural inhibitor geminin show reciprocal fluctuations in their protein levels due to cell cycle-dependent proteolysis. Here, we show that the protein levels of Cdt1 and geminin are persisten...
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| Autores principales: | , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3492748/ https://ncbi.nlm.nih.gov/pubmed/22096080 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.068676 |
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