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Cdt1 downregulation by proteolysis and geminin inhibition prevents DNA re-replication in Xenopus
In late mitosis and G1, Mcm2–7 are assembled onto replication origins to ‘license' them for initiation. At other cell cycle stages, licensing is inhibited, thus ensuring that origins fire only once per cell cycle. Three additional factors—the origin recognition complex, Cdc6 and Cdt1—are requir...
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| Udgivet i: | EMBO J |
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| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2004
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC545810/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15616577/ https://ncbi.nlm.nih.govhttps://doi.org/10.1038/sj.emboj.7600520 |
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