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A Cdt1–geminin complex licenses chromatin for DNA replication and prevents rereplication during S phase in Xenopus
Initiation of DNA synthesis involves the loading of the MCM2–7 helicase onto chromatin by Cdt1 (origin licensing). Geminin is thought to prevent relicensing by binding and inhibiting Cdt1. Here we show, using Xenopus egg extracts, that geminin binding to Cdt1 is not sufficient to block its activity...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2006
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1698883/ https://ncbi.nlm.nih.gov/pubmed/17124498 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601436 |
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