Lentiviral Transduction of CD34(+) Cells Induces Genome-Wide Epigenetic Modifications

Epigenetic modifications may occur during in vitro manipulations of stem cells but these effects have remained unexplored in the context of cell and gene therapy protocols. In an experimental model of ex vivo gene modification for hematopoietic gene therapy, human CD34(+) cells were cultured shortly...

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Main Authors: Yamagata, Yoshiaki, Parietti, Véronique, Stockholm, Daniel, Corre, Guillaume, Poinsignon, Catherine, Touleimat, Nizar, Delafoy, Damien, Besse, Céline, Tost, Jörg, Galy, Anne, Paldi, András
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3492239/
https://ncbi.nlm.nih.gov/pubmed/23145033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0048943
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