Lentiviral Transduction of CD34(+) Cells Induces Genome-Wide Epigenetic Modifications

Epigenetic modifications may occur during in vitro manipulations of stem cells but these effects have remained unexplored in the context of cell and gene therapy protocols. In an experimental model of ex vivo gene modification for hematopoietic gene therapy, human CD34(+) cells were cultured shortly...

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Bibliografiske detaljer
Main Authors: Yamagata, Yoshiaki, Parietti, Véronique, Stockholm, Daniel, Corre, Guillaume, Poinsignon, Catherine, Touleimat, Nizar, Delafoy, Damien, Besse, Céline, Tost, Jörg, Galy, Anne, Paldi, András
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3492239/
https://ncbi.nlm.nih.gov/pubmed/23145033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0048943
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