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Lentiviral Transduction of CD34(+) Cells Induces Genome-Wide Epigenetic Modifications
Epigenetic modifications may occur during in vitro manipulations of stem cells but these effects have remained unexplored in the context of cell and gene therapy protocols. In an experimental model of ex vivo gene modification for hematopoietic gene therapy, human CD34(+) cells were cultured shortly...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3492239/ https://ncbi.nlm.nih.gov/pubmed/23145033 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0048943 |
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